Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria

The emergence of multidrug and extensively drug-resistant pathogenic bacteria able to resist the action a wide range antibiotics is becoming growing problem for public health. search new compounds with potential help in reversion bacterial resistance plays an important role current medicinal chemistry research. Under this scope, efflux pumps are responsible antimicrobials, their inhibition could reverse resistance. In study, reversing activity series xanthones was investigated. Firstly, docking studies were performed AcrAB-TolC pump homology model NorA pump. Then, effects twenty xanthone derivatives on growth evaluated Staphylococcus aureus 272123 acrA gene-inactivated mutant Salmonella enterica serovar Typhimurium SL1344 (SE03). Their inhibitory properties assessed using real-time fluorimetry. Assays concerning these towards biofilm formation quorum sensing have also been performed. Results showed that halogenated phenylmethanamine derivative displayed interesting profile, as far concerned. To best our knowledge, first report inhibitors.